Aug 01, 2001
Frontiers of Physical Measurements and Analysis in Biology
Dr. David Kleinfeld
http://www-physics.ucsd.edu/neurophysics/
Chemists and physicists have been instrumental in the design of
essential technologies for the study of nervous systems. We will
review how the confluence of inspiration from biology and the
application of physical principles and modern physical techniques
has led to new imaging and new analysis procedures. Examples will
be taken from metabolic based contrast procedures such as
functional optical imaging, optical coherence tomography, and
functional magnetic resonance imaging. Further examples are direct
measurement of neuronal activity based on optical-based molecular
contrast agents of ion concentration or voltage, the use of
optical sectioning, particular multi-photon induced fluorescence,
and finally, on measurements of external fields such as with
magnetoencepalography. In addition to solely physical techniques,
we will describe the use of modern spectral and statistical
techniques in the analysis of data, particularly data from
multi-site measurements.
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