Recreational mathematics involves mathematical puzzles and games, often appealing to children and untrained adults, inspiring their further study of the subject. Can a similar analogy be drawn in biology? Without making any claims of usefulness, we will explore a wide range of puzzles and paradoxes from the living world: Can single cells be toroidal in nature? What would an animal from Flatland look like? Can cells “literally” talk to each other? Can single cells think? Can cells act as a mason and build out of rocks? Finally, we will discuss and share initiatives to democratize science and highlight the role of curiosity and observation in exploring the microscopic world.